The TiMe Cohort hosted the third-annual Tissue Microenvironment (TiMe) Symposium on April 26, 2019 at the Beckman Institute for Advanced Science and Technology. This year over 90 participants across 15 departments from the University of Illinois participated to share the diverse research related to the tissue microenvironment.. Several faculty members provided research talks spanning biomechanics, molecular imaging, cancer, and other aspects of the microenvironment. Prof. Dennis Discher from the University of Pennsylvania served as keynote speaker, and Prof. Rashid Bashir, Dean of The Grainger College of Engineering at Illinois provided the lunchtime talk. Four plenary talks were presented by Illinois faculty members Stephen A. Boppart, Shuming Nie, Wawosz Dobrucki, and Amy Waggoner Johnson. The TiMe T32 scholars presented three-minute lightning talks to showcase the myriad of inquiries the current cohort is actively researching. The session was concluded with a poster session featuring 25 posters. Profs. Marina Marjanovic, Gregory Underhill, Marni Boppart, John Erdman, Jeff Chan, and Rex Gaskins worked together to select the three winners for the poster session. The winners for the best poster awards were Luke Akin, Anuj Yadav, and Mai Ngo.